Transgenerational Effects of PTSD or Traumatic Stress: Do Telomeres Reach Across the Generations?
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چکیده
In the last few decades, research has focused strongly on identifying biomarkers that are associated with stressand trauma-related disorders. This research provided the empirical evidence for several etiological models that explain the pathways from physiological symptoms to psychological disorders and vice versa. One of the best-known is McEwen and Stellar’s allostatic load (AL) model, which describes the multidimensional effects of physiological and psychological stress [13]. In the AL model, an organism’s need to meet its external demands (i.e., environmental influences perceived as stress) is termed allostasis.
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Transgenerational effects of PTSD or traumatic stress: do telomeres reach across the generations?
Traumatic stress can alter allostatis and therefore mediate the development of psychological disorders. Recent evidence from molecular studies has shown that telomere length a measure of cellular aging is strongly influenced by a broad spectrum of stress. Telomere erosion might be accelerated by traumatic stress, and traumatic stress has shown to be associated with the risk of developing chroni...
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